Practical Guide to First-Order Multiplet Analysis, 1H NMR

Guest

"A Practical Guide to First-Order Multiplet Analysis in 1H NMR spectroscopy."

Hoye, T. R.; Hanson, P. R.; Vyvyan, J. R. J. Org. Chem. 1994, 59, 4096-4103.
http://dx.doi.org/10.1021%2Fjo00094a018

Discusses deduction of proper set of coupling constant (J) values from a complex first-order multiplet. Uses systematic analysis of line spacings and construction of "inverse splitting trees." Contains a systematic set of graphical representations of common dd's. ddd's and dddd's.

(This material was reproduced
from The Stoltz Group Technique Website
http://stoltz.caltech.edu/forum)

Guest · Posted: Wed Aug 19, 2009 2:48 am Post subject:

There has been a follow-up to this paper.

See: Hoye, T. R.; Zhao, H. J. Org. Chem., 2002, 67, 4014-16. at http://pubs.acs.org/doi/abs/10.1021/jo001139v

Instead of having to re-create the coupling tree, you can very easily deduce the coupling constants via an algorithm. It works for all first order multiplets, easy to very complex examples are given.